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Article

Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2014

Hall Kathryn T, Nelson Christopher P, Davis Roger B, Buring Julie E, Kirsch Irving, Mittleman Murray A, Loscalzo Joseph, Samani Nilesh J, Ridker Paul M, Kaptchuk Ted J, Chasman Daniel I

Abstract excerpt

OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways. This study aimed to confirm preliminary association of COMT genetic variation with incident cardiovascular disease (CVD). It further aimed to evaluate whether aspirin, a commonly used CVD prevention agent, modified the potential association of COMT with...

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Identifiers

PMID: 25035343
DOI: 10.1161/ATVBAHA.114.303845
PMCID: PMC4148908

Genes

COMT
MAF

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