Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.

doi:10.3945/jn.110.132506

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Article

Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.

The Journal of nutrition - 1 Feb 2011

Wernimont Susan M, Raiszadeh Farbod, Stover Patrick J, Rimm Eric B, Hunter David J, Tang Wenbo, Cassano Patricia A

Abstract excerpt

The enzymes serine hydroxymethyltransferase 1 (gene name SHMT1) and methylenetetrahydrofolate reductase (gene name MTHFR) regulate key reactions in folate-mediated one-carbon metabolism. Common genetic variants with the potential to influence disease risk exist in both genes. A prior report from the Normative Aging Study indicated no association of the SHMT1 rs1979277 SNP with cardiovascular disease (CVD), but a...

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PMID: 21178087
DOI: 10.3945/jn.110.132506
PMCID: PMC3021444

Genes

MTHFR
SHMT1
NHS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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