Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium.

doi:10.1161/CIRCGENETICS.113.000108

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Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium.

Circulation. Cardiovascular genetics - 1 Oct 2013

Kleber Marcus E, Seppälä Ilkka, Pilz Stefan, Hoffmann Michael M, Tomaschitz Andreas, Oksala Niku, Raitoharju Emma, Lyytikäinen Leo-Pekka, Mäkelä Kari-Matti, Laaksonen Reijo, Kähönen Mika, Raitakari Olli T, Huang Jie, Kienreich Katharina, Fahrleitner-Pammer Astrid, Drechsler Christiane, Krane Vera, Boehm Bernhard O, Koenig Wolfgang, Wanner Christoph, Lehtimäki Terho, März Winfried, Meinitzer Andreas

Abstract excerpt

BACKGROUND: Low serum levels of the amino acid derivative, homoarginine, have been associated with increased risk of total and cardiovascular mortality. Homoarginine deficiency may be related to renal and heart diseases, but the pathophysiologic role of homoarginine and the genetic regulation of its serum levels are largely unknown. METHODS AND RESULTS: In 3041 patients of the Ludwigshafen Risk and Cardiovascular...

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PMID: 24047826
DOI: 10.1161/CIRCGENETICS.113.000108

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