Article
B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Jun 2016
Ding Y P, Pedersen E K R, Johansson S, Gregory J F, Ueland P M, Svingen G F T, Helgeland Ø, Meyer K, Fredriksen Å, Nygård O K
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate dehydrogenase (MTHFD1) catalyzes three sequential reactions that metabolize derivatives of tetrahydrofolate (THF) in folate-dependent one-carbon metabolism. Impaired MTHFD1 flux has been linked to disturbed lipid metabolism and oxidative stress. However, limited information is available on its relation to the development of atherothrombotic cardiovascular disease. METHODS AND...
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