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Article

Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke.

Scientific reports - 17 Mar 2016

Seppälä Ilkka, Kleber Marcus E, Bevan Steve, Lyytikäinen Leo-Pekka, Oksala Niku, Hernesniemi Jussi A, Mäkelä Kari-Matti, Rothwell Peter M, Sudlow Cathie, Dichgans Martin, Mononen Nina, Vlachopoulou Efthymia, Sinisalo Juha, Delgado Graciela E, Laaksonen Reijo, Koskinen Tuomas, Scharnagl Hubert, Kähönen Mika, Markus Hugh S, März Winfried, Lehtimäki Terho

Abstract excerpt

Asymmetric and symmetric dimethylarginines (ADMA and SDMA) impair nitric oxide bioavailability and have been implicated in the pathogenesis of atrial fibrillation (AF). Alanine-glyoxylate aminotransferase 2 (AGXT2) is the only enzyme capable of metabolizing both of the dimethylarginines. We hypothesized that two functional AGXT2 missense variants (rs37369, V140I; rs16899974, V498L) are associated with AF and its...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26984639
DOI: 10.1038/srep23207
PMCID: PMC4794714

Genes

AGXT2

Variants

rs37369
rs37369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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