Article
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
Journal of the American College of Cardiology - 8 Jul 2008
Antoniades Charalambos, Shirodaria Cheerag, Van Assche Tim, Cunnington Colin, Tegeder Irmgard, Lötsch Jörn, Guzik Tomasz J, Leeson Paul, Diesch Jonathan, Tousoulis Dimitris, Stefanadis Christodoulos, Costigan Michael, Woolf Clifford J, Alp Nicholas J, Channon Keith M
Abstract excerpt
OBJECTIVES: This study sought to determine the effects of endogenous tetrahydrobiopterin (BH4) bioavailability on endothelial nitric oxide synthase (eNOS) coupling, nitric oxide (NO) bioavailability, and vascular superoxide production in patients with coronary artery disease (CAD). BACKGROUND: GTP-cyclohydrolase I, encoded by the GCH1 gene, is the rate-limiting enzyme in the biosynthesis of BH4, an eNOS cofactor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.