Article
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
The American journal of clinical nutrition - 1 May 2010
Lai Chao-Qiang, Parnell Laurence D, Troen Aron M, Shen Jian, Caouette Heather, Warodomwichit Daruneewan, Lee Yu-Chi, Crott Jimmy W, Qiu Wei Qiao, Rosenberg Irwin H, Tucker Katherine L, Ordovás José M
Abstract excerpt
BACKGROUND: The S-adenosylmethionine synthetase type 1 (MAT1A) gene encodes a key enzyme in one-carbon nutrient metabolism. OBJECTIVE: This study aimed to determine the association of MAT1A variants with homocysteine, DNA damage, and cardiovascular disease (CVD). DESIGN: Eight variants of MAT1A were examined for associations with hypertension, stroke, CVD, homocysteine, and DNA damage in 1006 participants of the...
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