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Identification of clinical and pharmacogenetic factors influencing metformin response in Type 2 diabetes mellitus.

Pharmacogenomics - 1 Aug 2023

Pérez-Gómez Noelia, Fernández-Ortega María Dolores, Elizari-Roncal Miren, Santos-Mazo Estefanía, la Maza-Pereg Laura de, Calvo Sara, Alcaraz Raquel, Sanz-Solas Antonio, Vinuesa Raquel, Saiz-Rodríguez Miriam

Abstract excerpt

Metformin, a hypoglycemic drug for Type 2 diabetes mellitus, shows variability in pharmacokinetics and response due to membrane transporters. This study followed 34 Type 2 diabetes mellitus patients on metformin treatment. Genetic variants in 11 metformin transport-related genes were analyzed, revealing associations. Specifically, SLC47A1 rs2289669 A/A and SLC22A4 rs1050152 T/T genotypes correlated with glycated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2
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Share to Organic Cation Transport Proteins
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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 37610884
DOI: 10.2217/pgs-2023-0109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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