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Article

Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes: A systematic review.

Medicine - 1 Jul 2018

Mofo Mato Edith Pascale, Guewo-Fokeng Magellan, Essop M Faadiel, Owira Peter Mark Oroma

Abstract excerpt

BACKGROUND: Metformin is one of the most commonly used drugs for the treatment of type 2 diabetes mellitus (T2DM). Despite its widespread use, there are considerable interindividual variations in metformin response, with about 35% of patients failing to achieve initial glycemic control. These variabilities that reflect phenotypic differences in drug disposition and action may indeed be due to polymorphisms in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29979413
DOI: 10.1097/MD.0000000000011349
PMCID: PMC6076123

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