Article
Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients.
Pharmacogenetics and genomics - 1 Sept 2012
Tarasova Linda, Kalnina Ineta, Geldnere Kristine, Bumbure Alda, Ritenberga Rota, Nikitina-Zake Liene, Fridmanis Davids, Vaivade Iveta, Pirags Valdis, Klovins Janis
Abstract excerpt
OBJECTIVE: Metformin is the most widely used oral antidiabetic drug for the treatment of type 2 diabetes (T2D). So far, the number of polymorphisms in SLC22A1, SLC22A2, and SLC47A1 genes coding for organic cation transporter 1 (OCT1), OCT2, and multidrug and toxin extrusion transporter 1 (MATE1) metformin transporters have been described in association with the efficacy of metformin. However, there is no...
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