Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.

doi:10.1530/EJE-16-0347

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Article

Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.

European journal of endocrinology - 1 Dec 2016

Zaharenko Linda, Kalnina Ineta, Geldnere Kristine, Konrade Ilze, Grinberga Solveiga, Židzik Jozef, Javorský Martin, Lejnieks Aivars, Nikitina-Zake Liene, Fridmanis Davids, Peculis Raitis, Radovica-Spalvina Ilze, Hartmane Dace, Pugovics Osvalds, Tkáč Ivan, Klimčáková Lucia, Pīrāgs Valdis, Klovins Janis

Abstract excerpt

OBJECTIVES: High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (tagging single nucleotide polymorphisms) from genomic regions coding for six metformin transporter genes with respect...

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PMID: 27609360
DOI: 10.1530/EJE-16-0347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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