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Article

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells.

Nature communications - 16 Nov 2016

Schmiedel Benjamin Joachim, Seumois Grégory, Samaniego-Castruita Daniela, Cayford Justin, Schulten Veronique, Chavez Lukas, Ay Ferhat, Sette Alessandro, Peters Bjoern, Vijayanand Pandurangan

Abstract excerpt

Asthma and autoimmune disease susceptibility has been strongly linked to genetic variants in the 17q21 haploblock that alter the expression of ORMDL3; however, the molecular mechanisms by which these variants perturb gene expression and the cell types in which this effect is most prominent are unclear. We found several 17q21 variants overlapped enhancers present mainly in primary immune cell types. CD4+ T cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCCTC-Binding Factor

Share to Chromosomes, Human, Pair 17

Share to Enhancer Elements, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 27848966
DOI: 10.1038/ncomms13426
PMCID: PMC5116091

Genes

ORMDL3
CTCF
CD4
ZPBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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