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Article

17q21 locus and ORMDL3: an increased risk for childhood asthma.

Pediatric research - 1 Jan 2014

Ono Jennie G, Worgall Tilla S, Worgall Stefan

Abstract excerpt

Genetic variations in the 17q21 locus are strongly associated with childhood nonallergic asthma. Expression of the 17q21 genes, orosomucoid like 3 (ORMDL3) and gasdermin B (GSMDB), is affected by these disease-associated variants. However, until recently, no functional connection of the protein products coded by these genes with asthma was known. Lately, it has been identified that ORMDL3 function has been...

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Source

Identifiers

PMID: 24165737
DOI: 10.1038/pr.2013.186

Genes

ORMDL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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