Article
Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.
The Journal of allergy and clinical immunology - 1 Oct 2015
Schedel Michaela, Michel Sven, Gaertner Vincent D, Toncheva Antoaneta A, Depner Martin, Binia Aristea, Schieck Maximilian, Rieger Marie T, Klopp Norman, von Berg Andrea, Bufe Albrecht, Laub Otto, Rietschel Ernst, Heinzmann Andrea, Simma Burkard, Vogelberg Christian, Genuneit Jon, Illig Thomas, Kabesch Michael
Abstract excerpt
BACKGROUND: Chromosome 17q21, harboring the orosomucoid 1-like 3 (ORMDL3) gene, has been consistently associated with childhood asthma in genome-wide association studies. OBJECTIVE: We investigated genetic variants in and around ORMDL3 that can change the function of ORMDL3 and thus contribute to asthma susceptibility. METHODS: We performed haplotype analyses and fine mapping of the ORMDL3 locus in a...
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