Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.

doi:10.1038/nature06014

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Article

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.

Nature - 26 Jul 2007

Moffatt Miriam F, Kabesch Michael, Liang Liming, Dixon Anna L, Strachan David, Heath Simon, Depner Martin, von Berg Andrea, Bufe Albrecht, Rietschel Ernst, Heinzmann Andrea, Simma Burkard, Frischer Thomas, Willis-Owen Saffron A G, Wong Kenny C C, Illig Thomas, Vogelberg Christian, Weiland Stephan K, von Mutius Erika, Abecasis Gonçalo R, Farrall Martin, Gut Ivo G, Lathrop G Mark, Cookson William O C

Abstract excerpt

Asthma is caused by a combination of poorly understood genetic and environmental factors. We have systematically mapped the effects of single nucleotide polymorphisms (SNPs) on the presence of childhood onset asthma by genome-wide association. We characterized more than 317,000 SNPs in DNA from 994 patients with childhood onset asthma and 1,243 non-asthmatics, using family and case-referent panels. Here we show...

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PMID: 17611496
DOI: 10.1038/nature06014

Genes

ORMDL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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