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Article

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion.

The Journal of allergy and clinical immunology - 1 Jun 2011

Lluis Anna, Schedel Michaela, Liu Jing, Illi Sabina, Depner Martin, von Mutius Erika, Kabesch Michael, Schaub Bianca

Abstract excerpt

BACKGROUND: In a genome-wide association study, genetic variants on chromosome 17q21 were strongly associated with childhood asthma and orosomucoid 1-like 3 (ORMDL3) gene expression. Regulation of the 17q21 locus and its immunologic relevance early in life have not been well characterized. OBJECT...

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Source

Identifiers

PMID: 21546069
DOI: 10.1016/j.jaci.2011.03.015

Genes

ORMDL3
GSDMA
GSDMB
PSMD3
TNF
ZPBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21546069-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion.PMID 21546069Read ↗

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