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Article

17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 Jun 2012

Marinho Susana, Custovic Adnan, Marsden Paul, Smith Jacky A, Simpson Angela

Abstract excerpt

BACKGROUND: Although an association between 17q12-21 and asthma has been replicated across different populations, some inconsistencies have been found between different studies. OBJECTIVE: We investigated the association between genetic variation in this region with asthma, lung function, airway inflammation, hyperresponsiveness (AHR), and atopy in a case-control study of United Kingdom adults. The interaction...

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Source

Identifiers

PMID: 22626592
DOI: 10.1016/j.anai.2012.03.002

Genes

AHR
IKZF3
GSDMA
GSDMB
ORMDL3
ZPBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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