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Article

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.

Cardiovascular diabetology - 10 Nov 2016

Lucas Elisa, Vila-Bedmar Rocio, Arcones Alba C, Cruces-Sande Marta, Cachofeiro Victoria, Mayor Federico, Murga Cristina

Abstract excerpt

BACKGROUND: The leading cause of death among the obese population is heart failure and stroke prompted by structural and functional changes in the heart. The molecular mechanisms that underlie obesity-related cardiac remodeling are complex, and include hemodynamic and metabolic alterations that ultimately affect the functionality of the myocardium. G protein-coupled receptor kinase 2 (GRK2) is an ubiquitous...

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Source

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Identifiers

PMID: 27832814
DOI: 10.1186/s12933-016-0474-6
PMCID: PMC5105284

Genes

GRK2
MFN1
OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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