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Article

A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload.

Journal of molecular and cellular cardiology - 1 May 2021

Bledzka Kamila M, Manaserh Iyad H, Grondolsky Jessica, Pfleger Jessica, Roy Rajika, Gao Erhe, Chuprun J Kurt, Koch Walter J, Schumacher Sarah M

Abstract excerpt

G protein-coupled receptor (GPCR) kinase 2 (GRK2) expression and activity are elevated early on in response to several forms of cardiovascular stress and are a hallmark of heart failure. Interestingly, though, in addition to its well-characterized role in regulating GPCRs, mounting evidence suggests a GRK2 "interactome" that underlies a great diversity in its functional roles. Several such GRK2 interacting...

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Identifiers

PMID: 33548241
DOI: 10.1016/j.yjmcc.2021.01.004
PMCID: PMC8101069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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