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Article

A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload.

Journal of molecular and cellular cardiology - 1 May 2021

Bledzka Kamila M, Manaserh Iyad H, Grondolsky Jessica, Pfleger Jessica, Roy Rajika, Gao Erhe, Chuprun J Kurt, Koch Walter J, Schumacher Sarah M

Abstract excerpt

G protein-coupled receptor (GPCR) kinase 2 (GRK2) expression and activity are elevated early on in response to several forms of cardiovascular stress and are a hallmark of heart failure. Interestingly, though, in addition to its well-characterized role in regulating GPCRs, mounting evidence suggests a GRK2 "interactome" that underlies a great diversity in its functional roles. Several such GRK2 interacting...

Topics

Animals
Biomarkers
Cardiomegaly
Disease Models, Animal
Disease Susceptibility
G-Protein-Coupled Receptor Kinase 2
Gene Expression
Mice
Mice, Transgenic
Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protein Binding

Protein Interaction Domains and Motifs

Signal Transduction

Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 33548241
DOI: 10.1016/j.yjmcc.2021.01.004
PMCID: PMC8101069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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