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Article

Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

Circulation research - 20 Jan 2012

Zhu Weizhong, Petrashevskaya Natalia, Ren Shuxun, Zhao Aizhi, Chakir Khalid, Gao Erhe, Chuprun J Kurt, Wang Yibin, Talan Mark, Dorn Gerald W, Lakatta Edward G, Koch Walter J, Feldman Arthur M, Xiao Rui-Ping

Abstract excerpt

RATIONALE: Phosphorylation of β(2)-adrenergic receptor (β(2)AR) by a family of serine/threonine kinases known as G protein-coupled receptor kinase (GRK) and protein kinase A (PKA) is a critical determinant of cardiac function. Upregulation of G protein-coupled receptor kinase 2 (GRK2) is a well-established causal factor of heart failure, but the underlying mechanism is poorly understood. OBJECTIVE: We sought to...

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Share to Adrenergic beta-Agonists
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Myocardial Contraction

Share to Pertussis Toxin

Share to Receptors, Adrenergic, beta-2

Share to Ventricular Function, Left

Share to Ventricular Remodeling

Source

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Identifiers

PMID: 22179058
DOI: 10.1161/CIRCRESAHA.111.253260
PMCID: PMC3282829

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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