Article
Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
Circulation research - 20 Jan 2012
Zhu Weizhong, Petrashevskaya Natalia, Ren Shuxun, Zhao Aizhi, Chakir Khalid, Gao Erhe, Chuprun J Kurt, Wang Yibin, Talan Mark, Dorn Gerald W, Lakatta Edward G, Koch Walter J, Feldman Arthur M, Xiao Rui-Ping
Abstract excerpt
RATIONALE: Phosphorylation of β(2)-adrenergic receptor (β(2)AR) by a family of serine/threonine kinases known as G protein-coupled receptor kinase (GRK) and protein kinase A (PKA) is a critical determinant of cardiac function. Upregulation of G protein-coupled receptor kinase 2 (GRK2) is a well-established causal factor of heart failure, but the underlying mechanism is poorly understood. OBJECTIVE: We sought to...
Topics
- Adrenergic beta-Agonists
- Animals
- Cardiomegaly
- Cells, Cultured
- Cyclic AMP-Dependent Protein Kinases
- Disease Models, Animal
- Dose-Response Relationship, Drug
- G-Protein-Coupled Receptor Kinase 2
- GTP-Binding Protein alpha Subunits, Gi-Go