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Article

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.

Journal of cardiovascular translational research - 1 Nov 2015

Sorriento Daniela, Santulli Gaetano, Franco Antonietta, Cipolletta Ersilia, Napolitano Luigi, Gambardella Jessica, Gomez-Monterrey Isabel, Campiglia Pietro, Trimarco Bruno, Iaccarino Guido, Ciccarelli Michele

Abstract excerpt

G protein coupled receptor kinase type 2 (GRK2) plays an important role in the development and maintenance of cardiac hypertrophy and heart failure even if its exact role is still unknown. In this study, we assessed the effect of GRK2 on the regulation of cardiac hypertrophy. In H9C2 cells, GRK2 overexpression increased atrial natriuretic factor (ANF) activity and enhanced phenylephrine-induced ANF response, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26224342
DOI: 10.1007/s12265-015-9646-0

Genes

GRK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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