Article
Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction.
Circulation - 1 May 2012
Raake Philip W, Zhang Xiaoying, Vinge Leif E, Brinks Henriette, Gao Erhe, Jaleel Naser, Li Yingxin, Tang Mingxin, Most Patrick, Dorn Gerald W, Houser Steven R, Katus Hugo A, Chen Xiongwen, Koch Walter J
Abstract excerpt
BACKGROUND: G-protein-coupled receptor kinase 2 (GRK2) is a primary regulator of β-adrenergic signaling in the heart. G-protein-coupled receptor kinase 2 ablation impedes heart failure development, but elucidation of the cellular mechanisms has not been achieved, and such elucidation is the aim of this study. METHODS AND RESULTS: Myocyte contractility, Ca(2+) handling and excitation-contraction coupling were...
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