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Article

A PRKAG2 mutation causes biphasic changes in myocardial AMPK activity and does not protect against ischemia.

Biochemical and biophysical research communications - 24 Aug 2007

Banerjee Sanjay K, Ramani Ravi, Saba Samir, Rager Jennifer, Tian Rong, Mathier Michael A, Ahmad Ferhaan

Abstract excerpt

Dominant mutations in the gamma2 regulatory subunit of AMP-activated protein kinase (AMPK), encoded by the gene PRKAG2, cause glycogen storage cardiomyopathy. We sought to elucidate the effect of the Thr400Asn (T400N) human mutation in a transgenic mouse (TGT400N) on AMPK activity, and its ability to protect the heart against ischemia-reperfusion injury. TGT400N hearts had markedly vacuolated myocytes, excessive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17597581
DOI: 10.1016/j.bbrc.2007.06.067

Genes

PRKAG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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