Article
G protein-coupled receptor kinases in normal and failing myocardium.
Frontiers in bioscience (Landmark edition) - 1 Jun 2011
Huang Zheng Maggie, Gold Jessica I, Koch Walter J
Abstract excerpt
Heart failure (HF) is the end stage of many underlying cardiovascular diseases and is among the leading causes of morbidity and mortality in industrialized countries. One of the striking characteristics of HF is the desensitization of G protein-coupled receptor (GPCR) signaling, particularly the beta-adrenergic receptor (betaAR) system. GPCR desensitization is initiated by phosphorylation by GPCR kinases (GRKs),...
Topics
- Animals
- G-Protein-Coupled Receptor Kinase 2
- G-Protein-Coupled Receptor Kinase 5
- G-Protein-Coupled Receptor Kinases
- Genetic Therapy
- Heart Failure
- Humans
- Mice
- Mice, Transgenic
- Models, Cardiovascular
- Myocardium