The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions.

doi:10.3390/cells10010167

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions.

Cells - 15 Jan 2021

Sorriento Daniela, Rusciano Maria Rosaria, Visco Valeria, Fiordelisi Antonella, Cerasuolo Federica Andrea, Poggio Paolo, Ciccarelli Michele, Iaccarino Guido

Abstract excerpt

Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in...

Topics

Animals
Diabetes Mellitus
Diabetes Mellitus, Type 2
G-Protein-Coupled Receptor Kinase 2
Heart Failure
Humans
Hypertension
Inflammation
Insulin
Insulin Resistance
Insulin-Secreting Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Muscle, Skeletal

Myocardium

Peptides

Phenotype

Phosphorylation

Risk

Source

Open in PubMed Open full text

Identifiers

PMID: 33467677
DOI: 10.3390/cells10010167
PMCID: PMC7830135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions.PMID 33467677Read ↗

Unraveling The Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic InterventionsSemantic proximity Read ↗

Insulin receptor signaling in normal and insulin-resistant states.Semantic proximity Read ↗

Insulin Resistance Syndrome- the Sensitive IRSSemantic proximity Read ↗

Impairment of the IR-IRS-PI3K-AKT signaling pathway in Insulin Resistance: New Insights into Insulin Resistance MechanismsSemantic proximity Read ↗

Insulin Resistance Mediates Crosstalk between Skeletal Muscle and the Heart to Prevent Cardiac DysfunctionSemantic proximity Read ↗

Molecular biology of insulin resistance.Semantic proximity Read ↗

[Insulin resistance and metabolic syndrome].Semantic proximity Read ↗

G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes.Semantic proximity Read ↗

Genetic Explication of Impaired Insulin Resistance in Genesis of Metabolic DiseasesSemantic proximity Read ↗

Signaling pathways and intervention for therapy of type 2 diabetes mellitusSemantic proximity Read ↗

Nonobese, insulin-deficient Ins2<sup>Akita</sup>mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodelingSemantic proximity Read ↗

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.