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Article

Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.

American journal of physiology. Heart and circulatory physiology - 1 May 2020

Lieu Melissa, Traynham Christopher J, de Lucia Claudio, Pfleger Jessica, Piedepalumbo Michela, Roy Rajika, Petovic Jennifer, Landesberg Gavin, Forrester Steven J, Hoffman Matthew, Grisanti Laurel A, Yuan Ancai, Gao Erhe, Drosatos Konstantinos, Eguchi Satoru, Scalia Rosario, Tilley Douglas G, Koch Walter J

Abstract excerpt

Nitric oxide (NO) and S-nitrosothiol (SNO) are considered cardio- and vasoprotective substances. We now understand that one mechanism in which NO/SNOs provide cardiovascular protection is through their direct inhibition of cardiac G protein-coupled receptor (GPCR) kinase 2 (GRK2) activity via S-nitrosylation of GRK2 at cysteine 340 (C340). This maintains GPCR homeostasis, including β-adrenergic receptors, through...

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Aging
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Heart
Heart Diseases

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PMID: 32216616
DOI: 10.1152/ajpheart.00094.2020
PMCID: PMC7346533

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