Article
Hepatic β-arrestin 2 is essential for maintaining euglycemia.
The Journal of clinical investigation - 1 Aug 2017
Zhu Lu, Rossi Mario, Cui Yinghong, Lee Regina J, Sakamoto Wataru, Perry Nicole A, Urs Nikhil M, Caron Marc G, Gurevich Vsevolod V, Godlewski Grzegorz, Kunos George, Chen Minyong, Chen Wei, Wess Jürgen
Abstract excerpt
An increase in hepatic glucose production (HGP) represents a key feature of type 2 diabetes. This deficiency in metabolic control of glucose production critically depends on enhanced signaling through hepatic glucagon receptors (GCGRs). Here, we have demonstrated that selective inactivation of the GPCR-associated protein β-arrestin 2 in hepatocytes of adult mice results in greatly increased hepatic GCGR...
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