Article

Pharmacological inhibition of G protein-coupled receptor kinase 5 decreases high-fat diet-induced hepatic steatosis in mice

2025-06-28

Abstract excerpt

<h4>ABSTRACT</h4> G protein-coupled receptor kinase 5 (GRK5) is implicated in the pathogenesis of obesity in both humans and rodent models. Our previous work demonstrated that genetic deletion or pharmacological inhibition of GRK5 suppresses 3T3-L1 adipocyte differentiation. Here, we assessed the small-molecule GRK5 inhibitor, GRK5-IN-2, for its effects on metabolic tissues and therapeutic potential in a diet-ind...

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Literature Corpus work: 01a4ef66-86ed-518b-8a3a-c44a35560fe1
DOI: 10.1101/2025.06.25.661655

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