Connexin 50 mutation lowers blood pressure in spontaneously hypertensive rat.

doi:10.33549/physiolres.933432

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Article

Connexin 50 mutation lowers blood pressure in spontaneously hypertensive rat.

Physiological research - 31 Mar 2017

Šeda O, Liška F, Pravenec M, Vernerová Z, Kazdová L, Křenová D, Zídek V, Šedová L, Krupková M, Křen V

Abstract excerpt

We assessed the effect of the previously uncovered gap junction protein alpha 8 (Gja8) mutation present in spontaneously hypertensive rat - dominant cataract (SHR-Dca) strain on blood pressure, metabolic profile, and heart and renal transcriptomes. Adult, standard chow-fed male rats of SHR and SHR-Dca strains were used. We found a significant, consistent 10-15 mmHg decrease in both systolic and diastolic blood...

Topics

Animals
Blood Pressure
Connexins
Gene Regulatory Networks
Heart
Hypertension
Kidney
Liver
Male
Mutation
Rats
Rats, Inbred SHR

Source

Open in PubMed

Identifiers

PMID: 27782748
DOI: 10.33549/physiolres.933432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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