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Spontaneously Hypertensive Rat Chromosome 2 with Mutant Connexin 50 Triggers Divergent Effects on Metabolic Syndrome Components.

Folia biologica - 1 Jan 2017

Šeda O, Křenová D, Šedová L, Kazdová L, Krupková M, Chylíková B, Liška F, Křen V

Abstract excerpt

Metabolic syndrome is a frequent condition with multifactorial aetiology. Previous studies indicated the presence of genetic determinants of metabolic syndrome components on rat chromosome 2 (RNO2) and syntenic regions of the human genome. Our aim was to further explore these findings using novel rat models. We derived the BN-Dca and BN-Lx.Dca congenic strains by introgression of a limited RNO2 region from a...

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PMID: 28557708
DOI: 10.14712/fb2017063020067

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