The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.

doi:10.1101/gr.103499.109

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Article

The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.

Genome research - 1 Jun 2010

Atanur Santosh S, Birol Inanç, Guryev Victor, Hirst Martin, Hummel Oliver, Morrissey Catherine, Behmoaras Jacques, Fernandez-Suarez Xose M, Johnson Michelle D, McLaren William M, Patone Giannino, Petretto Enrico, Plessy Charles, Rockland Kathleen S, Rockland Charles, Saar Kathrin, Zhao Yongjun, Carninci Piero, Flicek Paul, Kurtz Ted, Cuppen Edwin, Pravenec Michal, Hubner Norbert, Jones Steven J M, Birney Ewan, Aitman Timothy J

Abstract excerpt

The spontaneously hypertensive rat (SHR) is the most widely studied animal model of hypertension. Scores of SHR quantitative loci (QTLs) have been mapped for hypertension and other phenotypes. We have sequenced the SHR/OlaIpcv genome at 10.7-fold coverage by paired-end sequencing on the Illumina platform. We identified 3.6 million high-quality single nucleotide polymorphisms (SNPs) between the SHR/OlaIpcv and...

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PMID: 20430781
DOI: 10.1101/gr.103499.109
PMCID: PMC2877576

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