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Article

Microphthalmia and cataract in rats with a novel point mutation in connexin 50 - L7Q.

Molecular vision - 7 May 2008

Liska Frantisek, Chylíková Blanka, Martínek Jindrich, Kren Vladimír

Abstract excerpt

PURPOSE: We isolated an autosomal semi-dominant cataract from our inbred SHR/OlaIpcv rat colony. Heterozygotes express pulverulent cataract with smaller eyes; homozygotes express marked microphthalmia with hypoplastic lens. We call this mutation Dca (for dominant cataract). In this study, we focus on the identification of the responsible gene. METHODS: We performed linkage mapping using 93 F2(SHR-Dca x PD)...

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Identifiers

PMID: 18470322
PMCID: PMC2373795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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