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Article

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis.

Human molecular genetics - 1 Dec 2016

Pingitore Piero, Dongiovanni Paola, Motta Benedetta Maria, Meroni Marica, Lepore Saverio Massimo, Mancina Rosellina Margherita, Pelusi Serena, Russo Cristina, Caddeo Andrea, Rossi Giorgio, Montalcini Tiziana, Pujia Arturo, Wiklund Olov, Valenti Luca, Romeo Stefano

Abstract excerpt

Liver fibrosis is a pathological scarring response to chronic hepatocellular injury and hepatic stellate cells (HSCs) are key players in this process. PNPLA3 I148M is a common variant robustly associated with liver fibrosis but the mechanisms underlying this association are unknown. We aimed to examine a) the effect of fibrogenic and proliferative stimuli on PNPLA3 levels in HSCs and b) the role of wild type and...

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Source

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Identifiers

PMID: 27742777
DOI: 10.1093/hmg/ddw341
PMCID: PMC5886043

Genes

PNPLA3
MMP2
TIMP1
TIMP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis.PMID 27742777Read ↗

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells.Semantic proximity Read ↗

PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells.Semantic proximity Read ↗

Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular CrosstalkSemantic proximity Read ↗

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells.Semantic proximity Read ↗

PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells.Semantic proximity Read ↗

Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.Semantic proximity Read ↗

IL-6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease.Semantic proximity Read ↗

Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH SettingsSemantic proximity Read ↗

PNPLA3 I148M Variant Activates Hepatic Stellate Cells via AMIGO2 Upregulation Using iPSC-Derived Model.Semantic proximity Read ↗

PNPLA3 I148M polymorphism and progressive liver disease.Semantic proximity Read ↗

Molecular basis of Progressive Familial Intrahepatic Cholestasis 3. A proteomics studySemantic proximity Read ↗

Contribution of PNPLA3 gene to the natural history of liver diseases.Semantic proximity Read ↗

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