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Article

Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular Crosstalk

12 Oct 2024

Abstract excerpt

AIMS: Since its discovery, the patatin-like phospholipase domain containing 3 (PNPLA3) (rs738409 C>G p.I148M) variant has been studied extensively to unravel its molecular function. Although several studies proved a causal relationship between the PNPLA3 I148M variant and MASLD development and particularly fibrosis, the pathological mechanisms promoting this phenotype have not yet been fully clarified. METHODS:...

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Liver Disease Diagnosis and Treatment
Liver Diseases and Immunity
Liver physiology and pathology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39394864
DOI: 10.1111/liv.16117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular CrosstalkPMID 39394864Read ↗

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells.Semantic proximity Read ↗

PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells.Semantic proximity Read ↗

IL-6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease.Semantic proximity Read ↗

Research progress, challenges and perspectives on PNPLA3 and its variants in Liver DiseasesSemantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis.Semantic proximity Read ↗

PNPLA3 I148M Variant Activates Hepatic Stellate Cells via AMIGO2 Upregulation Using iPSC-Derived Model.Semantic proximity Read ↗

PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date.Semantic proximity Read ↗

The PNPLA3 I148M Variant Is Associated with Immune Cell Infiltration and Advanced Fibrosis in MASLD: A Prospective Genotype-Phenotype StudySemantic proximity Read ↗

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells.Semantic proximity Read ↗

Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.Semantic proximity Read ↗

The PNPLA3 I148M variant is associated with immune cell infiltration and advanced fibrosis in MASLD: a prospective genotype-phenotype study.Semantic proximity Read ↗

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