Article
PNPLA3 I148M Variant Activates Hepatic Stellate Cells via AMIGO2 Upregulation Using iPSC-Derived Model.
Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2026
Toshida Katsuya, Takeishi Kazuki, Itoh Shinji, Kurihara Takeshi, Motomura Takashi, Ishikawa Takuma, Iwasaki Hitoshi, Mita Junya, Nakayama Yuki, Tomiyama Takahiro, Iseda Norifumi, Florentino Rodrigo M, Toshima Takeo, Soto-Gutierrez Alejandro, Yoshizumi Tomoharu
Abstract excerpt
BACKGROUND AND AIMS: A variant in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) was reported to be related to metabolic-associated fatty liver disease. However, the mechanism by which this variant leads to liver fibrosis has not been unveiled yet. Using induced pluripotent stem cell (iPSC)-derived hepatic stellate cells (iHSC) containing a single nucleotide polymorphism (SNP) within PNPLA3,...
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