Article

Molecular basis of Progressive Familial Intrahepatic Cholestasis 3. A proteomics study

2023-06-15

Abstract excerpt

<h4>Background and aims</h4> Progressive familiar intrahepatic cholestasis type 3 (PFIC3) is a severe rare liver disease which affects between 1/50,000 to 1/100,000 children. In physiological conditions, bile is produced by the liver and stored in the gallbladder, then it flows to the small intestine to play its role in fat digestion. To prevent tissue damage, bile acids are kept into phospholipid micelles. Mutat...

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Literature Corpus work: 97e307ee-40ae-5625-a8e5-c21775824c3e
DOI: 10.1101/2023.06.15.545058

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