Article
Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.
Hepatology communications - 1 Oct 2022
Ericson Elke, Bergenholm Linnéa, Andréasson Anne-Christine, Dix Carly I, Knöchel Jane, Hansson Sara F, Lee Richard, Schumi Jennifer, Antonsson Madeleine, Fjellström Ola, Nasr Patrik, Liljeblad Mathias, Carlsson Björn, Kechagias Stergios, Lindén Daniel, Ekstedt Mattias
Abstract excerpt
In nonalcoholic fatty liver disease (NAFLD) the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 variant is a contributor. In mice, the Pnpla3 148M variant accumulates on lipid droplets and probably leads to sequestration of a lipase cofactor leading to impaired mobilization of triglycerides. To advance our understanding of the localization and abundance of PNPLA3 protein in humans, we used liver...
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