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Article

PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells.

International journal of molecular sciences - 18 Nov 2020

Bruschi Francesca Virginia, Tardelli Matteo, Einwallner Elisa, Claudel Thierry, Trauner Michael

Abstract excerpt

Liver fibrosis represents the wound healing response to sustained hepatic injury with activation of hepatic stellate cells (HSCs). The I148M variant of the PNPLA3 gene represents a risk factor for development of severe liver fibrosis. Activated HSCs carrying the I148M variant display exacerbated pro-inflammatory and pro-fibrogenic features. We aimed to examine whether the I148M variant may impair Hedgehog and Yap...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33218077
DOI: 10.3390/ijms21228711
PMCID: PMC7698885

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PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells.PMID 33218077Read ↗

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