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Article

Contribution of PNPLA3 gene to the natural history of liver diseases.

Acta gastro-enterologica Belgica - 1 Jan 2000

Trépo E

Abstract excerpt

n 2008, a genome-wide association studies (GWAS) showed a strong association between a variant (rs738409 C>G p.I148M) in the PNPLA3 and nonalcoholic fatty liver disease. Further replication studies have shown robust associations between PNPLA3 and steatosis, fibrosis/cirrhosis, and hepatocellular carcinoma on a background of metabolic, alcoholic, and viral insults. The PNPLA3 protein has lipase activity towards...

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Identifiers

PMID: 29364097

Genes

PNPLA3

Provenance

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Related research

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Contribution of PNPLA3 gene to the natural history of liver diseases.PMID 29364097Read ↗

Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics.Semantic proximity Read ↗

PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date.Semantic proximity Read ↗

PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver disease.Semantic proximity Read ↗

PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease.Semantic proximity Read ↗

PNPLA3 gene in liver diseasesSemantic proximity Read ↗

Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease.Semantic proximity Read ↗

PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.Semantic proximity Read ↗

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.Semantic proximity Read ↗

Integrating PNPLA3 into clinical risk prediction.Semantic proximity Read ↗

PNPLA3 I148M polymorphism and progressive liver disease.Semantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD.Semantic proximity Read ↗

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