IL-6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease.

doi:10.1016/j.jhep.2022.08.022

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Article

IL-6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease.

Journal of hepatology - 1 Jan 2023

Park Jiwoon, Zhao Yuanyuan, Zhang Fan, Zhang Shaoyan, Kwong Andrew C, Zhang Yujie, Hoffmann Hans-Heinrich, Bushweller Leila, Wu Xin, Ashbrook Alison W, Stefanovic Branko, Chen Shuyang, Branch Andrea D, Mason Christopher E, Jung Jae U, Rice Charles M, Wu Xianfang

Abstract excerpt

BACKGROUND & AIMS: A number of genetic polymorphisms have been associated with susceptibility to or protection against non-alcoholic fatty liver disease (NAFLD), but the underlying mechanisms remain unknown. Here, we focused on the rs738409 C>G single nucleotide polymorphism (SNP), which produces the I148M variant of patatin-like phospholipase domain-containing protein 3 (PNPLA3) and is strongly associated with...

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Identifiers

PMID: 36049612
DOI: 10.1016/j.jhep.2022.08.022
PMCID: PMC9772150

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