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Article

PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells.

PloS one - 1 Jan 2021

Rady Brian, Nishio Takahiro, Dhar Debanjan, Liu Xiao, Erion Mark, Kisseleva Tatiana, Brenner David A, Pocai Alessandro

Abstract excerpt

Non-alcoholic steatohepatitis (NASH) results, in part, from the interaction of metabolic derangements with predisposing genetic variants, leading to liver-related complications and mortality. The strongest genetic determinant is a highly prevalent missense variant in patatin-like phospholipase domain-containing protein 3 (PNPLA3 p.I148M). In human liver hepatocytes PNPLA3 localizes to the surface of lipid...

Topics

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Down-Regulation
Hepatic Stellate Cells
Lipase
Lipid Droplets
Mutation, Missense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Non-alcoholic Fatty Liver Disease

Primary Cell Culture

Transforming Growth Factor beta

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Identifiers

PMID: 34879108
DOI: 10.1371/journal.pone.0260721
PMCID: PMC8654208

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PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells.PMID 34879108Read ↗

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PNPLA3 I148M Variant Activates Hepatic Stellate Cells via AMIGO2 Upregulation Using iPSC-Derived Model.Semantic proximity Read ↗

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