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Article

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells.

Human molecular genetics - 1 Aug 2014

Pirazzi Carlo, Valenti Luca, Motta Benedetta Maria, Pingitore Piero, Hedfalk Kristina, Mancina Rosellina Margherita, Burza Maria Antonella, Indiveri Cesare, Ferro Yvelise, Montalcini Tiziana, Maglio Cristina, Dongiovanni Paola, Fargion Silvia, Rametta Raffaela, Pujia Arturo, Andersson Linda, Ghosal Saswati, Levin Malin, Wiklund Olov, Iacovino Michelina, Borén Jan, Romeo Stefano

Abstract excerpt

Retinoids are micronutrients that are stored as retinyl esters in the retina and hepatic stellate cells (HSCs). HSCs are key players in fibrogenesis in chronic liver diseases. The enzyme responsible for hydrolysis and release of retinyl esters from HSCs is unknown and the relationship between retinoid metabolism and liver disease remains unclear. We hypothesize that the patatin-like phospholipase...

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Diterpenes
Hep G2 Cells
Hepatic Stellate Cells
Lipid Droplets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Primary Cell Culture

Retinol-Binding Proteins, Plasma

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Identifiers

PMID: 24670599
DOI: 10.1093/hmg/ddu121
PMCID: PMC4082369

Genes

PNPLA3

Variants

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PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells.PMID 24670599Read ↗

The Genetic Variant I148M in PNPLA3 Is Associated With Increased Hepatic Retinyl-Palmitate Storage in Humans.Semantic proximity Read ↗

Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular CrosstalkSemantic proximity Read ↗

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells.Semantic proximity Read ↗

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis.Semantic proximity Read ↗

Statin-associated regulation of hepatic PNPLA3 in patients without known liver disease.Semantic proximity Read ↗

Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD).Semantic proximity Read ↗

PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity.Semantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

IL-6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease.Semantic proximity Read ↗

PNPLA3—A Potential Therapeutic Target for Personalized Treatment of Chronic Liver DiseaseSemantic proximity Read ↗

Research progress, challenges and perspectives on PNPLA3 and its variants in Liver DiseasesSemantic proximity Read ↗

Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH SettingsSemantic proximity Read ↗

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