Article
The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells.
Hepatology (Baltimore, Md.) - 1 Jun 2017
Bruschi Francesca Virginia, Claudel Thierry, Tardelli Matteo, Caligiuri Alessandra, Stulnig Thomas M, Marra Fabio, Trauner Michael
Abstract excerpt
The genetic polymorphism I148M of patatin-like phospholipase domain-containing 3 (PNPLA3) is robustly associated with hepatic steatosis and its progression to steatohepatitis, fibrosis, and cancer. Hepatic stellate cells (HSCs) are key players in the development of liver fibrosis, but the role of PNPLA3 and its variant I148M in this process is poorly understood. Here we analyzed the expression of PNPLA3 during...
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