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Article

PNPLA3 I148M polymorphism and progressive liver disease.

World journal of gastroenterology - 7 Nov 2013

Dongiovanni Paola, Donati Benedetta, Fares Roberta, Lombardi Rosa, Mancina Rosellina Margherita, Romeo Stefano, Valenti Luca

Abstract excerpt

The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is involved in lipid metabolism, has recently been identified as a major determinant of liver fat content. Several studies confirmed that the I148M variant predisposes towards the full spectrum of liver damage associated with fatty liver: from simple...

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Share to Cholangitis, Sclerosing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemochromatosis

Share to Hepatitis B, Chronic

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Share to Liver Cirrhosis

Share to Liver Cirrhosis, Alcoholic

Share to Non-alcoholic Fatty Liver Disease

Source

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Identifiers

PMID: 24222941
DOI: 10.3748/wjg.v19.i41.6969
PMCID: PMC3819533

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

PNPLA3 I148M polymorphism and progressive liver disease.PMID 24222941Read ↗

PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.Semantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.Semantic proximity Read ↗

Patatin-Like Phospholipase Domain-Containing 3 I148M Variant Is Associated with Liver Steatosis and Fat Distribution in Chronic Hepatitis B.Semantic proximity Read ↗

PNPLA3 I148M and Hepatocellular Carcinoma.Semantic proximity Read ↗

Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis.Semantic proximity Read ↗

Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.Semantic proximity Read ↗

PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date.Semantic proximity Read ↗

The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrientsSemantic proximity Read ↗

PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease.Semantic proximity Read ↗

Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD.Semantic proximity Read ↗

Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B.Semantic proximity Read ↗

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