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Identification of Novel Intronic SNPs in Transporter Genes Associated with Metformin Side Effects.

Genes - 11 Aug 2023

Schweighofer Natascha, Strasser Moritz, Obermayer Anna, Trummer Olivia, Sourij Harald, Sourij Caren, Obermayer-Pietsch Barbara

Abstract excerpt

Metformin is a widely used and effective medication in type 2 diabetes (T2DM) as well as in polycystic ovary syndrome (PCOS). Single nucleotide polymorphisms (SNPs) contribute to the occurrence of metformin side effects. The aim of the present study was to identify intronic genetic variants modifying the occurrence of metformin side effects and to replicate them in individuals with T2DM and in women with PCOS. We...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37628660
DOI: 10.3390/genes14081609
PMCID: PMC10454417

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