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Article

Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.

The Journal of pharmacology and experimental therapeutics - 1 Oct 2010

Chen Ligong, Takizawa Miho, Chen Eugene, Schlessinger Avner, Segenthelar Julie, Choi Ji Ha, Sali Andej, Kubo Michiaki, Nakamura Shinko, Iwamoto Yasuhiko, Iwasaki Naoko, Giacomini Kathleen M

Abstract excerpt

Organic cation transporter 1 (OCT1; SLC22A1) seems to play a role in the efficacy and disposition of the widely used antidiabetic drug metformin. Genetic variants in OCT1 have been identified largely in European populations. Metformin is increasingly being used in Asian populations where the incidence of type 2 diabetes (T2D) is on the rise. The goal of this study is to identify genetic variants of OCT1 in...

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Identifiers

PMID: 20639304
DOI: 10.1124/jpet.110.170159
PMCID: PMC2957788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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