Article
Renal tubular epithelium-targeted peroxisome proliferator-activated receptor-γ maintains the epithelial phenotype and antagonizes renal fibrogenesis.
Oncotarget - 4 Oct 2016
Zhao Min, Chen Ying, Ding Guixia, Xu Ying, Bai Mi, Zhang Yue, Jia Zhanjun, Huang Songming, Zhang Aihua
Abstract excerpt
Accumulating evidence suggests that loss of the renal tubular epithelial phenotype plays an important role in the pathogenesis of renal tubulointerstitial fibrosis. Systemic activation of peroxisome proliferator-activated receptor γ (PPAR-γ) has been shown to be protective against renal fibrosis, although the mechanisms are poorly understood. The present study aimed to define the role of renal tubular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.