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Article

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

15 Feb 2012

Abstract excerpt

Scarring of the kidney is a major public health concern, directly promoting loss of kidney function. To understand the role of microRNA (miRNA) in the progression of kidney scarring in response to injury, we investigated changes in miRNA expression in two kidney fibrosis models and identified 24 commonly up-regulated miRNAs. Among them, miR-21 was highly elevated in both animal models and in human transplanted...

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Liver Disease Diagnosis and Treatment
MicroRNA in disease regulation
Renal and related cancers

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22344686
DOI: 10.1126/scitranslmed.3003205

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