Article
PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.
American journal of physiology. Renal physiology - 1 May 2012
Lan Rongpei, Geng Hui, Polichnowski Aaron J, Singha Prajjal K, Saikumar Pothana, McEwen Donald G, Griffin Karen A, Koesters Robert, Weinberg Joel M, Bidani Anil K, Kriz Wilhelm, Venkatachalam Manjeri A
Abstract excerpt
We investigated the signaling basis for tubule pathology during fibrosis after renal injury. Numerous signaling pathways are activated physiologically to direct tubule regeneration after acute kidney injury (AKI) but several persist pathologically after repair. Among these, transforming growth factor (TGF)-β is particularly important because it controls epithelial differentiation and profibrotic cytokine...
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