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Article

Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice.

PloS one - 1 Jan 2016

Svensson Kristoffer, Schnyder Svenia, Cardel Bettina, Handschin Christoph

Abstract excerpt

The kidney has a high energy demand and is dependent on oxidative metabolism for ATP production. Accordingly, the kidney is rich in mitochondria, and mitochondrial dysfunction is a common denominator for several renal diseases. While the mitochondrial master regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is highly expressed in kidney, its role in renal physiology is so far unclear....

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Diet, High-Fat
Kidney Diseases
Kidney Tubules
Lipid Metabolism
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

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Identifiers

PMID: 27463191
DOI: 10.1371/journal.pone.0158716
PMCID: PMC4963111

Genes

PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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